Sydney Brenner on the Genetics of Caenorhabditis elegans
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منابع مشابه
Sydney Brenner on the Genetics of Caenorhabditis elegans.
Sydney Brenner decided on his lifelong scientific goals on one cold day in April 1953.Hewas a 26-year-old graduate student in Oxford at the time. “What I remember inOxford is being hungry all the time, and cold,” he told me. Crick and Watson had just built the double helix model, and Brenner and a few others took a road trip to Cambridge to see it before it was announced to the rest of the worl...
متن کاملThe genetics of Caenorhabditis elegans.
Methods are described for the isolation, complementation and mapping of mutants of Caenorhabditis elegans, a small free-living nematode worm. About 300 EMS-induced mutants affecting behavior and morphology have been characterized and about one hundred genes have been defined. Mutations in 77 of these alter the movement of the animal. Estimates of the induced mutation frequency of both the visib...
متن کاملDevelopmental genetics of the Caenorhabditis elegans pharynx
The Caenorhabditis elegans pharynx is a rhythmically pumping organ composed initially of 80 cells that, through fusions, amount to 62 cells in the adult worm. During the first 100 min of development, most future pharyngeal cells are born and gather into a double-plate primordium surrounded by a basal lamina. All pharyngeal cells express the transcription factor PHA-4, of which the concentration...
متن کاملThe genetics of feeding in Caenorhabditis elegans.
The pharynx of Caenorhabditis elegans is a nearly self-contained neuromuscular organ responsible for feeding. To identify genes involved in the development or function of the excitable cells of the pharynx, I screened for worms with visible defects in pharyngeal feeding behavior. Fifty-two mutations identified 35 genes, at least 22 previously unknown. The genes broke down into three broad class...
متن کاملGenetics of Aging in Caenorhabditis elegans
A dissection of longevity in Caenorhabditis elegans reveals that animal life span is influenced by genes, environment, and stochastic factors. From molecules to physiology, a remarkable degree of evolutionary conservation is seen.
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ژورنال
عنوان ژورنال: Genetics
سال: 2016
ISSN: 1943-2631
DOI: 10.1534/genetics.116.194084